Regional brain heating during microwave exposure (2.06 GHz), warm-water immersion, environmental heating and exercise

1998 ◽  
Vol 19 (6) ◽  
pp. 341-353 ◽  
Author(s):  
T. J. Walters ◽  
K. L. Ryan ◽  
J. C. Belcher ◽  
J. M. Doyle ◽  
M. R. Tehrany ◽  
...  
Author(s):  
Manju Gari ◽  
Kumari Ranjeeta ◽  
Lakhan Majhee ◽  
Akhilesh Kumar ◽  
Sumit Kumar Mahato

Background: Pain is the most common reason patients seek medical care. Increased level of monoamines (serotonin and norepinephrine) in synaptic clefts lead to changes in pain threshold and induce antinociception. The study was carried out to evaluate antinociceptive effect of paroxetine in albino rats and to probe into its possible mechanism of action. The study was carried out to evaluate anti-nociceptive effect of paroxetine in albino rats.Methods: Male Albino rats of average weight 150-240gms were used. The drugs used were paroxetine 5mg/Kg, pethidine 5mg/kg (standard drug). Anti-nociceptive effect tested by using thermal method i.e. Tail flick response and Tail warm water immersion method.Results: In this study, Anti-nociceptive effect of respective drugs were measured by using two methods i.e. tail flick test and tail warm water immersion method at 0 min., 30 min., 60 min. and 90min.after administration of drugs. Reaction time started to increase from baseline at 0 min. and peak effect was seen at 60 min. then it started to decrease at 90 min. in almost all the groups except in control group.Conclusions: Paroxetine have significant analgesic effect in acute pain, which may be mediated via central and peripheral mechanisms. Efficacy of Paroxetine is almost equal to that of standard drug pethidine in acute pain management.


JAMA ◽  
1967 ◽  
Vol 200 (8) ◽  
pp. 716b-716
Keyword(s):  

2020 ◽  
Vol 185 (11-12) ◽  
pp. e2039-e2043
Author(s):  
Eric M Vinceslio ◽  
Zane Fayos ◽  
Aaron Bernadette ◽  
Jan-Michael Van Gent

Abstract Introduction Cold weather injuries require prompt warm water immersion therapy, which proves to be a difficult task in the cold austere environment. Current guidelines recommend 104 °F water immersion, but producing and maintaining large volumes of warm water is challenging in sub-freezing temperatures. We describe a novel process of utilizing a sous vide immersion circulator to maintain warm fluids for immersion therapy and efficient fluid rewarming in a cold forward-deployed setting for the treatment of cold weather injuries in an effort to bridge the gap between current medical guidelines and practices. Materials and Methods Large water cans were warmed to 104 °F with the immersion circulator. A thermometer was inserted into a 1-inch steak, frozen to 30 °F, and placed in a basin with only the warmed water while the internal temperature was monitored until physiologic temperature was achieved. The time to this endpoint was recorded. A 1-L bag of normal saline and a 450-mL bag of whole blood were also separately warmed by the same technique. The temperature of the normal saline was monitored at 0-, 5-, 7-, 8-, 9-, and 10 -minute intervals. The process was similarly repeated, measuring the whole blood temperature at 0-, 5-, 7-, and 10-minute intervals. Results Ambient internal tent temperatures averaged 54 °F; outdoor temperatures were consistently sub-freezing. The 5-gallon cans of water at ambient temperature heated to 104 °F in 15 minutes. The water temperature remained constant for 3 weeks with the circulator running. The frozen steak started at 30 °F and reached 98 °F in 52 minutes and 45 seconds. The bag of normal saline and whole blood, refrigerated to 39 °F, achieved temperatures of 102 °F and 94 °F respectively after 10 minutes. Conclusion A heating immersion circulator device is a lightweight, flameless, and inexpensive way to consistently heat large volumes of water for treatment of cold weather injuries, hypothermia, and whole blood rewarming in a cold austere environment.


1997 ◽  
Vol 162 (9) ◽  
pp. 610-611 ◽  
Author(s):  
William Humphrey ◽  
Ronald Ellyson
Keyword(s):  

2009 ◽  
Vol 7 (1) ◽  
Author(s):  
Bente Grüner Sveälv ◽  
Åsa Cider ◽  
Margareta Scharin Täng ◽  
Eva Angwald ◽  
Dimitris Kardassis ◽  
...  

2003 ◽  
Vol 94 (2) ◽  
pp. 598-603 ◽  
Author(s):  
Catherine O'Brien ◽  
Scott J. Montain

This study was conducted to determine whether hypohydration (Hy) alters blood flow, skin temperature, or cold-induced vasodilation (CIVD) during peripheral cooling. Fourteen subjects sat in a thermoneutral environment (27°C) during 15-min warm-water (42°C) and 30-min cold-water (4°C) finger immersion (FI) while euhydrated (Eu) and, again, during Hy. Hy (−4% body weight) was induced before FI by exercise-heat exposure (38°C, 30% relative humidity) with no fluid replacement, whereas during Eu, fluid intake maintained body weight. Finger pad blood flow [as measured by laser-Doppler flux (LDF)] and nail bed (Tnb), pad (Tpad), and core (Tc) temperatures were measured. LDF decreased similarly during Eu and Hy (32 ± 10 and 33 ± 13% of peak during warm-water immersion). Mean Tnb and Tpad were similar between Eu (7.1 ± 1.0 and 11.5 ± 1.6°C) and Hy (7.4 ± 1.3 and 12.6 ± 2.1°C). CIVD parameters (e.g., nadir, onset time, apex) were similar between trials, except Tpad nadir was higher during Hy (10.4 ± 3.8°C) than during Eu (7.9 ± 1.6°C), which was attributed to higher Tc in six subjects during Hy (37.5 ± 0.2°C), compared with during Eu (37.1 ± 0.1°C). The results of this study provide no evidence that Hy alters finger blood flow, skin temperature, or CIVD during peripheral cooling.


JAMA ◽  
1967 ◽  
Vol 200 (8) ◽  
pp. 681-683 ◽  
Author(s):  
L. J. Buckels
Keyword(s):  

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